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Axel Methner

Axel Methner, MD
Professor of Neurology
Principal Investigator

Vita

Current Appointment

  • Vice chair and Professor of Neurology
  • Principal Investigator
  • University Medicine Mainz

Education and Dissertation

  • Abitur (High school diploma, 1985)
  • Medical schools:
  • Freie Universität Berlin (1987-1993)
  • Université de Paris XI (1990-1991) 4th year attachment
  • Final year elective periods at Brown University (RI) and Université de Lausanne (1992-1993)
  • Dissertation (M.D. thesis) at the Institute for Pharmacology, Freie Universität Berlin (1996) Thesis Project (magna cum laude): Inhibition of PAF synthesis in human neutrophil granulocytes with inhibitors of lyso-PAF- acetyltransferase. Advisor: Prof. Dr. F. v. Bruchhausen

Clinical and Scientific Training

  • Surgical internship at the University Hospital Tübingen (1993-1994)
  • Postgraduate course in Molecular Neurobiology at the University of Hamburg (1994-1996)
    Research Project (very good): Cloning and characterization of novel G-protein-coupled receptors. Advisor: Prof. Chica Schaller
  • Residency in neurology at the University Hospital Eppendorf (1996-2001): 12 months psychiatric rotation • 15 months neurological intensive care • 20 months general neurology • 6 months neurosonography • 9 months clinical neurophysiology • 12 months outpatient neurology • 6 months research rotation
  • Postdoc with Dr. Rainer Reinscheid at the Institut für Zellbiochemie und klinische Neurobiologie Hamburg (1997-1998, in addition to clinical work during leisure time)
  • Fellowship in Neurological Intensive Care at the University Hospital Eppendorf (2002-2003)

Academic Appointments

  • Principal Investigator (1999-2004) at the Zentrum für Molekulare Neurobiologie Hamburg (ZMNH). Focus on neuroprotective genes with special emphasis on G-protein-coupled receptors in paradigms investigating ischemic preconditioning and chronic oxidative stress in the nervous system • fully funded by grants
  • Principal Investigator (2005-2012) at the Department of Neurology, University Düsseldorf

Hospital Appointments

  • Head of the Clinical Laboratory for CSF Analyses and Neuropharmacology (2001-2004) at the Department of Neurology, University of Hamburg. Clinical evaluation of cerebrospinal fluid proteins and cytology. Auto-antibody testing, neuropharmacological testing in Parkinson's disease etc.
  • Attending Neurologist (2004) at a large teaching hospital in Hamburg. 600 beds, six stroke beds • responsible for all in- and outpatients • neurosonography • EEG • neuroradiology
  • Attending Neurologist and Faculty (2005-2012) at the University Hospital Düsseldorf

Licensure and Certifications

  • German medical state exam (good) June 1993
  • License to practice medicine, 1995
  • ECFMG certificate, 1996
  • Certificate in Molecular Biology (magna cum laude), University of Hamburg, 1996
  • Board Certification for Neurology, 2002
  • Board Certification for Cerebrospinal fluid analysis, 2004
  • Board Certification for Neurological Intensive Care, 200
  • Habilitation in Neurology "The role of G-protein-coupled signaling in glutamate toxicity", 2004
  • Extraordinary Professorship at the Heinrich Heine University Düsseldorf, 2010
  • Professorship at the Johannes Gutenberg University Mainz, 2012

Professional Memberships

  • Deutsche Gesellschaft für Neurologie
  • Neurowissenschaftliche Gesellschaft
  • Deutsche Gesellschaft für Neurogenetik
  • Deutsche Gesellschaft für Liquoranalytik und klinische Neuropharmakologie

Honors and Awards

  • Bourse d'etat, Université de Paris XI, 1991
  • Biomedical exchange program MHH Hannover travel award 1992
  • Best poster prize Deutsche Gesellschaft für Neurologie annual meeting 2001
  • Best poster prize Deutsche Gesellschaft für Neurologie annual meeting 2002
  • Honorary lecture at the "Wandertreffen südwestdeutscher Neurologen und Psychiater", 2002
  • Arthur Kling, M.D. award for entrepreneurial science, 2002
  • Dr. Martini-Preis (oldest prize for the advancement of clinically relevant basic science in Germany), 2004
  • Ellison Foundation scholarship to attend the Biology of Aging summer course at the MBL in Woods Hole, 2010

Current Team Members (in order of appearance)

Philipp Schippers

Philipp Schippers
MD student

Calcium and cell death

Felix Wunder

Felix Wunder
MD student

Calcium and cell death

Teresa Boldt

Teresa Schacht (Boldt)
M.Sc., Postdoc

Resistance against oxidative stress

Alireza Pouya
M.Sc., PhD student

Resistance against oxidative stress

Ann-Kathrin Herrmann
PhD student

Calcium and cell death

Verena Wüllner

Verena Wüllner
Dipl.-Biol., technician

Christina Wolf

Christina Wolf
PhD student

Resistance against oxidative stress

Alexander Gawlitza

Alexander Gawlitza
MD, Postdoc

Resistance against oxidative stress

Former Members (in order of appearance)

Lisa Pflaum

Lisa Pflaum
MD student

Resistance against oxidative stress

Verena Dries

Verena Dries
MD student

Ca2+ and cell death

Alina Fritz
MD student

Resistance against oxidative stress

Christina Hoffmann
MD student

Mediators of cell survival in neuronal stem cells

Dima Lisak

Dima Lisak, M.Sc.
PhD student

Calcium and cell death

Annika Pfeiffer

Annika Pfeiffer, M.Sc.
PhD student

Resistance against oxidative stress

Frank Leypoldt

Frank Leypoldt, MD
Medical Dissertation Universität Hamburg 2004

Thesis: Identifikation von transkriptionell hochregulierten Genen bei der Differenzierung von humanen, neuronalen Vorläuferzellen Ntera2 cl. D1

Jan Lewerenz

Jan Lewerenz, MD
Medical Dissertation Universität Hamburg 2003

Thesis: Molecular Mechanisms of Protection against Oxidative Glutamate Toxicity in the Neuronal Cell Line HT22

Gebhard-Koch-Promotionspreis für Zellbiochemie und Neurobiologie 2004

Julius Steinbeck

Julius Steinbeck, MD
Medical Dissertation Universität Hamburg 2005

Thesis: Ischemic preconditioning of rat primary neuronal cultures

Patrick Joost

Patrick Joost, MD
Postdoc

 

Naoya Koseki

Naoya Koseki, MD
Medical Dissertation Universität Hamburg 2005

Thesis: Bedeutung gerinnungsrelevanter Genpolymorphismen für den Verlauf des ischämischen Schlaganfalls

Mathias Klein

Mathias Klein, MD
Postdoc

 

Jan Wessig

Jan Wessig, MD
Postdoc

 

Mert Sahin

Mert Sahin, PhD
Dissertation in Biology, Universität Hamburg 2006

Thesis: Protection Against Oxidative Glutamate Toxicity Mediated by the Mouse (Mus musculus) Orphan Receptor GPR

Anna Pantlen

Anna Pantlen, MD
Medical Dissertation Universität Hamburg 2006

Thesis: Klonierung und Charakterisierung G-Protein gekoppelter Rezeptoren

Julia Letz

Julia Letz, Ärztin
MD student

Project: A giant superoxid dismutase, thesis not yet finished

Ben Westphalen

Ben Westphalen, MD
Medical Dissertation Universität Hamburg 2009

Thesis: Mechanism of BI-1-mediated cell death protection

Heinrich-Netheler-Promotionspreis für Molekularbiologie 2009

Ambrish Saxena

Ambrish Saxena, MSci
Research associate

 

Susanne Thomsen

Susanne Thomsen
Technician

 

Mai-Ly Tran Tien

Mai-Ly Tran Tien
MD student

Thesis: Resistance against oxidative stress, not yet finished

Svenja Frede

Svenja Frede
MD student

Thesis: Resistance against oxidative stress, not yet finished

Sonja Dittmer

Sonja Dittmer, PhD
Dissertation in Biology, Heinrich-Heine-Universität Düsseldorf

Thesis: Mechanisms of Cytoprotection Mediated by G-Protein coupled Receptor GPR39

Armagan Özgür

Armagan Oezguer
Diploma student

Thesis: Charakterisierung der Ca2+-bindenden Necab-Proteinfamilies

Saskia Unkel

Saskia Unkel
MD student

Mediators of cell survival in neuronal stem cells

Kyosuke Uno

Kyosuke Uno
Visiting Scientist

Resistance against oxidative stress

Rebecca Noack

Rebecca Noack, Dipl.-Biol.
Dissertation in Biology, Heinrich-Heine-Universität Düsseldorf

Thesis: Resistance Against Oxidative Glutamate Toxicity: Functional Characterization of Amino Acid Antiporter Subunit xCT, Purinergic ATP Receptor P2X3 and Mitochondrial Fission Factor GDAP1

Jörn Habicht

Jörn Habicht
Diploma student

Thesis: Characterization of the BI-1 protein family

Diamandis Toutzaris

Diamandis Toutzaris, Arzt
Medical dissertation Heinrich-Heine-Universität Düsseldorf

Thesis: Funktionelle Charakterisierung eines neuen Proteins mit einer Superoxiddismutase- Domäne

Nadine Henke, Dipl.-Biol.
Dissertation in Biology, Heinrich-Heine-Universität Düsseldorf

Thesis: How Stromal Interaction Molecule 1 (STIM1) and Store Operated Calcium Entry (SOCE) affect mitochondrial energy metabolism and neuronal function
Deutsch-polnischer Preis für Nachwuchswissenschaftler 2012

Lars Schneider

Lars Schneider, Dipl.-Biochem.
PhD student

Thesis: Calcium and cell death, not yet finished

Zsuzsa Kovacs

Zsusza Kaiser (neé Kovacs), Dipl.-Biol.
Dissertation in Biology, Heinrich-Heine-Universität Düsseldorf

Thesis: Die Rolle des Homeobox-Transkriptionsfaktors TOX3 in neuralen Progenitor-Zellen und Stammzellen

Nina Sanders

Nina Sanders
MD student

Thesis: Resistance against oxidative stress, not yet finished

Caroline Sladek

Caroline Sladek

BA thesis: Resistance against oxidative stress

Imane Bouchachia

Imane Bouchachia
MD student

Thesis: Resistance against oxidative stress, not yet finished

Ann-Kristin Müller

Ann-Kristin Müller
MD student

Thesis: Biomarker, not yet finished

Katrin Knoll

BA thesis: Rolle des intrazellulären Kalziumhaushaltes in der Pathogenese des Morbus Charcot-Marie-Tooth CMT4A

Sven Kroesen

BA thesis: Generierung zellulärer Knockout-Modelle von „Ganglioside-Induced Differentiation-Associated Protein 1“ (GDAP1) und „Ganglioside-Induced Differentiation- Associated Protein 1 like-1“ (GDAP1L1)

Vitalij Endres
MD student

Thesis: Calcium and cell death, not yet finished

Philipp Albrecht

Philipp Albrecht, MD
Postdoc

Resistance against oxidative stress, Biomarkers

Andrea Issberner

Andrea Issberner
Technician

Resistance against oxidative stress

Julia Schneider

Julia Schneider, B.A.

Thesis: Effekte des anti-apoptotischen Proteins Bcl-xL auf die mitochondriale Funktion