methnerlab: PUBLICATIONS
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BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival.
Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, Gliem M, Hofstetter HH, Zanger K, Bultynck G, Parys JB, De Smedt H, Kindler T, Adams-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A.
Cell Death Differ. 2016 Feb;23(2):358-68. doi: 10.1038/cdd.2015.115. Epub 2015 Oct 16.

Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.
Epplen DB, Prukop T, Nientiedt T, Albrecht P, Arlt FA, Stassart RM, Kassmann CM, Methner A, Nave KA, Werner HB, Sereda MW.
Ann Clin Transl Neurol. 2015 Aug;2(8):787-96. doi: 10.1002/acn3.219. Epub 2015 Jun 24.

A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis.
Droby A, Panagoulias M, Albrecht P, Reuter E, Duning T, Hildebrandt A, Wiendl H, Zipp F, Methner A.
Br J Ophthalmol. 2015 Aug 25. pii: bjophthalmol-2014-306015. doi: 10.1136/bjophthalmol-2014-306015. [Epub ahead of print]

Retinal pathology in idiopathic moyamoya angiopathy detected by optical coherence tomography.
Albrecht P, Blasberg C, Lukas S, Ringelstein M, Müller AK, Harmel J, Kadas EM, Finis D, Guthoff R, Aktas O, Hartung HP, Paul F, Brandt AU, Berlit P, Methner A, Kraemer M
Neurology. 2015 Aug 11;85(6):521-7. doi: 10.1212/WNL.0000000000001832. Epub 2015 Jul 15.

The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA2+-filling state.
Lisak DA, Schacht T, Enders V, Habicht J, Kiviluoto S, Schneider J, Henke N, Bultynck G, Methner A.
Biochim Biophys Acta. 2015 Sep;1853(9):2104-14. doi: 10.1016/j.bbamcr.2015.03.002. Epub 2015 Mar 9.


Subtle retinal pathology in amyotrophic lateral sclerosis.
Ringelstein M, Albrecht P, Südmeyer M, Harmel J, Müller AK, Keser N, Finis D, Ferrea S, Guthoff R, Schnitzler A, Hartung HP, Methner A, Aktas O.
Ann Clin Transl Neurol. 2014 Apr;1(4):290-7. doi: 10.1002/acn3.46.

Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger.
Bultynck G, Kiviluoto S, Methner A.
Sci Signal. 2014 Sep 16;7(343):pe22. doi: 10.1126/scisignal.2005764.

Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.
Kovacs Z, Schacht T, Herrmann AK, Albrecht P, Lefkimmiatis K, Methner A.
Biochem J. 2014 Aug 15;462(1):125-32. doi: 10.1042/BJ20131198.

Regulators of mitochondrial Ca(2+) homeostasis in cerebral ischemia.
Schäfer MK, Pfeiffer A, Jaeckel M, Pouya A, Dolga AM, Methner A.
Cell Tissue Res. 2014 Aug;357(2):395-405. doi: 10.1007/s00441-014-1807-y.

Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease.
Czeredys M, Gruszczynska-Biegala J, Schacht T, Methner A, Kuznicki J.
Front Mol Neurosci. 2013 Nov 25;6:42. doi: 10.3389/fnmol.2013.00042. eCollection 2013.

Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress.
Pfeiffer A, Jaeckel M, Lewerenz J, Noack R, Pouya A, Schacht T, Hoffmann C, Winter J, Schweiger S, Schäfer MK, Methner A.
Br J Pharmacol. 2014 Apr;171(8):2147-58. doi: 10.1111/bph.12549.


Interaction of Bcl-2 with the Autophagy-Related Protein GABARAP -- Biophysical Characterization and Functional Implications.
Ma P, Schwarten M, Schneider L, Boeske A, Henke N, Lisak D, Weber S, Mohrlüder J, Stoldt M, Strodel B, Methner A, Hoffmann S, Weiergräber OH, Willbold D.
J Biol Chem. 2013 Nov 15. [Epub ahead of print]

Phosphoinositide 3-kinases upregulate system xc- via eIF2α and ATF4 - a pathway active in glioblastomas and epilepsy.
Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Meakin PJ, Karpel-Massler G, Hayes JD, Aronica E, Smolders I, Ludolph A, Methner A, Massie A, Hardingham GE, Maher P.
Antioxid Redox Signal. 2013 Nov 12. [Epub ahead of print]

Genetic shift of env V3 loop viral sequences in patients with HIV-associated neurocognitive disorder during antiretroviral therapy.
Eggers C, Müller O, Thordsen I, Schreiber M, Methner A.
J Neurovirol. 2013 Oct 8. [Epub ahead of print]

Bax Inhibitor-1-mediated Ca(2+) leak is decreased by cytosolic acidosis.
Kiviluoto S, Luyten T, Schneider L, Lisak D, Rojas-Rivera D, Welkenhuyzen K, Missaen L, De Smedt H, Parys JB, Hetz C, Methner A, Bultynck G.
Cell Calcium. 2013 Sep;54(3):186-92. doi: 10.1016/j.ceca.2013.06.002

Promoting myelination in an in vitro mouse model of the peripheral nerve system: the effect of wine ingredients.
Stettner M, Wolffram K, Mausberg AK, Albrecht P, Derksen A, Methner A, Dehmel T, Hartung HP, Dietrich H, Kieseier BC.
PLoS One. 2013 Jun 7;8(6):e66079. doi: 10.1371/journal.pone.0066079.

Extracellular cyclic GMP and its derivatives GMP and guanosine protect from oxidative glutamate toxicity.
Albrecht P, Henke N, Tien ML, Issberner A, Bouchachia I, Maher P, Lewerenz J, Methner A.
Neurochem Int. 2013 Apr;62(5):610-9. doi: 10.1016/j.neuint.2013.01.019.

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress.
Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, Kaznacheyeva E, Maher P, Methner A.
Cell Death Dis. 2013 Jan 24;4:e470. doi: 10.1038/cddis.2012.216.

Multiple sclerosis in 2012: Novel therapeutic options and drug targets in MS.
Methner A, Zipp F.
Nat Rev Neurol. 2013 Feb;9(2):72-3. doi: 10.1038/nrneurol.2012.277.


Retinal neurodegeneration in Wilson's disease revealed by spectral domain optical coherence tomography.
Albrecht P, Müller AK, Ringelstein M, Finis D, Geerling G, Cohn E, Aktas O, Hartung HP, Hefter H, Methner A.
PLoS One. 2012;7(11):e49825. doi: 10.1371/journal.pone.0049825.

An emboligenic pulmonary abscess leading to ischemic stroke and secondary brain abscess.
Albrecht P, Stettner M, Husseini L, Macht S, Jander S, Mackenzie C, Oesterlee U, Slotty P, Methner A, Hartung HP, Aktas O.
BMC Neurol. 2012 Nov 5;12:133. doi: 10.1186/1471-2377-12-133.

Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress.
Henke N, Albrecht P, Pfeiffer A, Toutzaris D, Zanger K, Methner A.
J Biol Chem. 2012 Dec 7;287(50):42042-52. doi: 10.1074/jbc.M112.417212.

Bax inhibitor-1 is a novel IP₃ receptor-interacting and -sensitizing protein.
Kiviluoto S, Schneider L, Luyten T, Vervliet T, Missiaen L, De Smedt H, Parys JB, Methner A, Bultynck G.
Cell Death Dis. 2012 Aug 9;3:e367. doi: 10.1038/cddis.2012.103.

Effects of dimethyl fumarate on neuroprotection and immunomodulation.
Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, Issberner A, Kovacs Z, Lewerenz J, Lisak D, Maher P, Mausberg AK, Quasthoff K, Zimmermann C, Hartung HP, Methner A.
J Neuroinflammation. 2012 Jul 7;9:163. doi: 10.1186/1742-2094-9-163.

Neuromyelitis optica following human papillomavirus vaccination.
Menge T, Cree B, Saleh A, Waterboer T, Berthele A, Kalluri SR, Hemmer B, Aktas O, Hartung HP, Methner A, Kieseier BC.
Neurology. 2012 Jul 17;79(3):285-7. doi: 10.1212/WNL.0b013e31825fdead.

The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.
Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P.
Antioxid Redox Signal. 2013 Feb 10;18(5):522-55. doi: 10.1089/ars.2011.4391.

A case of relapsing-remitting neuroborreliosis? Challenges in the differential diagnosis of recurrent myelitis.
Albrecht P, Henke N, Lehmann HC, Macht S, Hefter H, Goebels N, Mackenzie C, Rupprecht TA, Fingerle V, Hartung HP, Methner A.
Case Rep Neurol. 2012 Jan;4(1):47-53. doi: 10.1159/000337223.

Optical coherence tomography in parkinsonian syndromes.
Albrecht P, Müller AK, Südmeyer M, Ferrea S, Ringelstein M, Cohn E, Aktas O, Dietlein T, Lappas A, Foerster A, Hartung HP, Schnitzler A, Methner A.
PLoS One. 2012;7(4):e34891. doi: 10.1371/journal.pone.0034891.

Degeneration of retinal layers in multiple sclerosis subtypes quantified by optical coherence tomography.
Albrecht P, Ringelstein M, Müller AK, Keser N, Dietlein T, Lappas A, Foerster A, Hartung HP, Aktas O, Methner A.
Mult Scler. 2012 Oct;18(10):1422-9.

The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
Bultynck G, Kiviluoto S, Henke N, Ivanova H, Schneider L, Rybalchenko V, Luyten T, Nuyts K, De Borggraeve W, Bezprozvanny I, Parys JB, De Smedt H, Missiaen L, Methner A.
J Biol Chem. 2012 Jan 20;287(4):2544-57. doi: 10.1074/jbc.M111.275354.

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression.
Lewerenz J, Sato H, Albrecht P, Henke N, Noack R, Methner A, Maher P.
Cell Death Differ. 2012 May;19(5):847-58. doi: 10.1038/cdd.2011.165.

Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential.
Noack R, Frede S, Albrecht P, Henke N, Pfeiffer A, Knoll K, Dehmel T, Meyer Zu Hörste G, Stettner M, Kieseier BC, Summer H, Golz S, Kochanski A, Wiedau-Pazos M, Arnold S, Lewerenz J, Methner A.
Hum Mol Genet. 2012 Jan 1;21(1):150-62. doi: 10.1093/hmg/ddr450.


POEMS syndrome. An interdisciplinary clinical challenge.
Braun SA, Albrecht P, Methner A, Hanneken S.
Hautarzt. 2011 Oct;62(10):722-5. doi: 10.1007/s00105-011-2239-1.

Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy.
Steinbeck JA, Henke N, Opatz J, Gruszczynska-Biegala J, Schneider L, Theiss S, Hamacher N, Steinfarz B, Golz S, Brüstle O, Kuznicki J, Methner A.
Exp Neurol. 2011 Dec;232(2):185-94. doi: 10.1016/j.expneurol.2011.08.022.

Guillain-Barré syndrome variant with prominent facial diplegia, limb paresthesia, and brisk reflexes.
Lehmann HC, Macht S, Jander S, Hartung HP, Methner A.
J Neurol. 2012 Feb;259(2):370-1. doi: 10.1007/s00415-011-6169-8.

The ancient cell death suppressor BAX inhibitor-1.
Henke N, Lisak DA, Schneider L, Habicht J, Pergande M, Methner A.
Cell Calcium. 2011 Jun 8. [Epub ahead of print]

Regulation of xCT expression and system [Formula: see text] function in neuronal cells.
Lewerenz J, Maher P, Methner A.
Amino Acids. 2011 Mar 3. [Epub ahead of print]

TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.
Dittmer S, Kovacs Z, Yuan SH, Siszler G, Kögl M, Summer H, Geerts A, Golz S, Shioda T, Methner A.
J Cell Sci. 2011 Jan 15;124(Pt 2): 252-60.


Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System x(c)- as a Neuroprotective Drug Target.
Albrecht P, Lewerenz J, Dittmer S, Noack R, Maher P, Methner A.
CNS Neurol Disord Drug Targets. 2010 Jul;9(3):373-82.

A novel giant peroxisomal superoxide dismutase motif-containing protein.
Toutzaris D, Lewerenz J, Albrecht P, Jensen LT, Letz J, Geerts A, Golz S, Methner A.
Free Radic Biol Med. 2010 Mar 15;48(6):811-20. [Epub ahead of print]


Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.
Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A.
J Neurochem. 2009 Oct;111(2):332-43.

Immunolocalization of STIM1 in the mouse brain.
Skibinska-Kijek A, Wisniewska MB, Gruszczynska-Biegala J, Methner A, Kuznicki J.
Acta Neurobiol Exp (Wars). 2009;69(4):413-28.

Free caspase activity in CSF of patients with dementia.
Albrecht P, Schmitz M, Otto M, Hemmer B, Zerr I, Hartung HP, Methner A.
J Neurol. 2009 Sep;256(9):1561-2.

Diffuse leptomeningeal astrocytoma in a patient with infantile epilepsy.
Warnke C, Lanzman RS, Klink B, Schellhammer F, Reifenberger G, Methner A.
Arch Neurol. 2009 Mar;66(3):408-9.

before 2009

The constitutively active orphan G-protein-coupled receptor GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor.
Dittmer S, Sahin M, Pantlen A, Saxena A, Toutzaris D, Pina AL, Geerts A, Golz S, Methner A.
J Biol Chem. 2008 Mar 14;283(11):7074-81.

Optical coherence tomography measures axonal loss in multiple sclerosis independently of optic neuritis.
Albrecht P, Fröhlich R, Hartung HP, Kieseier BC, Methner A.
J Neurol. 2007 Nov;254(11):1595-6.

Induction of Bcl-2 by functional regulation of G-protein coupled receptors protects from oxidative glutamate toxicity by increasing glutathione.
Sahin M, Saxena A, Joost P, Lewerenz J, Methner A.
Free Radic Res. 2006 Nov;40(11):1113-23.

Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc- protects from oxidative glutamate toxicity.
Lewerenz J, Klein M, Methner A.
J Neurochem. 2006 Aug;98(3):916-25.

Translational downregulation of the noncatalytic growth factor receptor TrkB.T1 by ischemic preconditioning of primary neurons.
Steinbeck JA, Methner A.
Gene Expr. 2005;12(2):99-106.

BI-1 protects cells from oxygen glucose deprivation by reducing the calcium content of the endoplasmic reticulum.
Westphalen BC, Wessig J, Leypoldt F, Arnold S, Methner A.
Cell Death Differ. 2005 Mar;12(3):304-6.

Vitamin B 12 plasma concentrations in Alzheimer disease.
Stuerenburg HJ, Mueller-Thomsen T, Methner A.
Neuro Endocrinol Lett. 2004 Jun;25(3):176-7.

Multiple vascular abnormalities and a paradoxical combination of vitamin B12 deficiency and thrombocytosis in a case with POEMS syndrome.
Lewerenz J, Gocht A, Hoeger PH, von den Driesch P, Eckert B, Lamszus K, Stuerenburg HJ, Methner A.
J Neurol. 2003 Dec;250(12):1488-91.

Short-term serum supplementation improves glucose-oxygen deprivation in primary cortical cultures grown under serum-free conditions.
Lewerenz J, Thomsen S, Steinbeck JA, Methner A.
Methods Cell Sci. 2003;25(3-4):227-36.

Activation of stimulatory heterotrimeric G proteins increases glutathione and protects neuronal cells against oxidative stress.
Lewerenz J, Letz J, Methner A.
J Neurochem. 2003 Oct;87(2):522-31.

Degenerate suppression PCR identifies the beta2-adrenergic receptor as upregulated by neuronal differentiation.
Lewerenz J, Leypoldt F, Methner A.
Gene Expr. 2003;11(2):105-16.

Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development.
Ignatov A, Lintzel J, Hermans-Borgmeyer I, Kreienkamp HJ, Joost P, Thomsen S, Methner A, Schaller HC.
J Neurosci. 2003 Feb 1;23(3):907-14.

Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands.
Joost P, Methner A.
Genome Biol. 2002 Oct 17;3(11):RESEARCH0063.

Neuronal differentiation of cultured human NTERA-2cl.D1 cells leads to increased expression of synapsins.
Leypoldt F, Flajolet M, Methner A.
Neurosci Lett. 2002 May 10;324(1):37-40.

Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation.
Methner A, Leypoldt F, Joost P, Lewerenz J.
Biochem Biophys Res Commun. 2001 Apr 27;283(1):48-56.

Identification of genes up-regulated by retinoic-acid-induced differentiation of the human neuronal precursor cell line NTERA-2 cl.D1.
Leypoldt F, Lewerenz J, Methner A.
J Neurochem. 2001 Feb;76(3):806-14.

Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse.
Hermey G, Methner A, Schaller HC, Hermans-Borgmeyer I.
Biochem Biophys Res Commun. 1999 Jan 8;254(1):273-9.

Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex.
Hermans-Borgmeyer I, Hampe W, Schinke B, Methner A, Nykjaer A, Süsens U, Fenger U, Herbarth B, Schaller HC.
Mech Dev. 1998 Jan;70(1-2):65-76.

A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development.
Methner A, Hermey G, Schinke B, Hermans-Borgmeyer I.
Biochem Biophys Res Commun. 1997 Apr 17;233(2):336-42.